Selenium E Complex
Vegetarian Formula * Dietary Supplement
Food Selenium E Complex
is a 100% Food
complex nutrient with extremely
important antioxidant properties.
Why another vitamin E?
Because most vitamin E sold is not
Food.
Natural vitamin E "as found in
Foods
is [d]-alpha tocopherol, whereas chemical synthesis
produces a mixture of eight epimers" [1] (natural
vitamin E has recently been renamed to be called
RRR-alpha-tocopherol
whereas the synthetic has now been renamed to all-rac-alpha-tocopherol,
though supplement labels rarely make this clear; on
supplement labels d-alpha-tocopherol is generally
"natural", whereas dl-alpha-tocopherol is synthetic
[2]). Natural RRR-alpha-tocopherol
has 1.7 - 4.0 times the free radical scavenging strength
of the other tocopherols,
RRR-alpha
tocopherol has 3 times the biological activity of the
alpha-tocotrienol form, and synthetic vitamin E simply
does not have the same biologic activity of natural
vitamin E (some synthetic forms have only 2% of the
biological activity of
RRR-alpha-tocopherol)
[2]. The biologic activity of vitamin E is based on its
ability to reverse specific vitamin E-deficiency
symptoms [2], therefore
it is a scientific
fact that, overall, synthetic vitamin E has less ability
to correct vitamin E deficiencies than
Food
vitamin E. There is an interesting
reason for this, which is that the body regulates plasma
vitamin E through a specific liver alpha-tocopherol
transfer protein, whereas it has no such protein for
other vitamin E forms [2]. Or in other words, the liver
produces a protein to handle vitamin E found in
Food,
but not for the synthetic forms!
Even mainstream researchers teach, "Vitamin E is the
exception to the paradigm that synthetic and natural
vitamins are the equivalent because their molecular
structures are identical...Synthetic vitamin E is
produced by commercially coupling trimethylhydroquinone
(TMHQ) with isophytol. This chemical reaction produces a
difficult-to-separate mixture of eight isomers" [3]
(vitamin E, of course, is not the only exception--all
nutrients are better if they are
Food).
Isolated natural vitamin E has been found to have twice
the bioavailability as synthetic vitamin E [4]. The form
of vitamin E found in
Food
has been found to be 2.7 times more better retained in
the body than a synthetic form [5]"this appears to be
because the body attempts to rid itself of synthetic
forms as quickly as possible [5].
Food Vitamin E
has been proven to have 12 micro moles per gram T.E. of
lipophilic ORAC (oxygen radical absorbance capacity)
[6]"ORAC is essentially a measurement of the ability to
quench free radicals (antioxidant ability). It is
interesting to note that so-called "natural" forms (like
succinate) do not even work like
Food Vitamin E"Even
the PDR
notes, "d-Alpha-Tocopherol succinate itself has no
antioxidant activity" [7], so why would anyone want that
for their vitamin E supplement?
Vitamin E is necessary for the optimal development and
maintenance of the nervous system as well as skeletal
muscle [3]. Vitamin E deficiency can lead to certain
anemias, nutritional muscular dystrophy, reproductive
problems, and hyperlipidemia [1]. Vitamin E has been
shown to reduce the risk of various cancers, coronary
heart disease, cataract formation, and even air
pollution [2,3]. It also is believed it may slow the
aging process and decrease exercise-induced oxidative
stress [2,3]. Artificial fats seem to increase the need
for vitamin E [8]. Vitamin E content is highest in
vegetable oils, also relatively high in avocados (4.31
i.u. each) [9] and rice bran [10].
What about selenium?
The three most common forms of selenium in supplements
are sodium selenite, seleniomethionine, and
Food
selenium. The predominant form of selenium found in the
body (and in
Food
selenium) is selenocysteine [11]. A
study using 247 mcg/day of high-selenium yeast found
that plasma selenium levels were 2-fold higher than
baseline values after 3 and 9 months and returned to
136% of baseline after 12 months, whereas there was a
32% increase in blood glutathione levels also seen after
9 months [12]. This change coincided with a 26% decrease
in protein-bound glutathione and a 44% decrease in the
ratio of protein-bound glutathione to blood glutathione.
The changes in glutathione and protein-bound glutathione
were highly correlated with changes in plasma selenium
levels and were believed to reflect a reduction in
oxidative stress, thus it appears that
Food
selenium is a much stronger antioxidant than non-food
forms. Oxidative stress can result in the production of
glycation end-products tend to also accumulate in the
brains of those who develop Alzheimer"s or similar forms
of dementia [13]. Selenium seems to support thyroid
hormone production, function as part of many enzymes,
have antioxidant effects, and supports cardiovascular
health [11]. It has been reported that yeast selenium
seems to reduce toxicity associated with cisplatin
chemotherapy [14] and cancer mortality in some [15].
Based on animal research, Dr. David Williams claims that
selenium is "better than a flu shot", because
selenium-deficiency "may cause a harmless strain of the
flu virus to mutate into a virulent pathogen" and that
selenium may reduce lung-damage associated with the flu
[16].
Sodium selenite is not a
Food,
but is the result of combining sodium hydroxide and
selenious acid; sodium selenite is commonly used to
remove green color from glass during glass manufacturing
[17]. Why would anyone want to take that as part of
their food supplement? Interestingly in 1999, the Nobel
prize in medicine was awarded for the finding that
humans need protein chaperones in order for minerals
like selenium to be absorbed into the cell.
Selenium mineral
salts do not contain protein chaperones, yet 100%
Food
Selenium E Complex
naturally contains
protein chaperones such as ceruloplasmin
and ATX1 [18,19].
100%
Food Selenium E Complex
also naturally contains superoxide dismutase (S.O.D.).
S.O.D. "is one of the most important enzymes that
functions as a cellular antioxidant...The absence of
this enzyme is lethal" [20]. The benefits of S.O.D. are
enhanced in the presence of vitamin E [21]. Studies show
that S.O.D. is helpful for heart, lung, joints, kidneys,
liver, muscles, and skin [20-22].
100%
Food Selenium E Complex
also contains rice bran and other vegetable fiber per
tablet. Both soluble and insoluble are important for
human health. Few women meet the National Cancer
Institute recommendations for fiber [23]. Dietary fiber
helps regulate nutrient absorption, sterol metabolism,
cecal fermentation, and stool weight [25]. Shortages may
lead to cholesterol problems, certain cancers, digestive
problems, cardiovascular concerns, and nutrient problems
[23,24]. Rice
bran is also a
Food
source of silicon and B vitamins [11,25,26].
It
is no wonder, that once they know the science, that
doctors interested in optimal natural health recommend
Food Selenium
E Complex as the preferred 100%
Food
source of natural vitamin E and selenium.
References
[1] Farrel PM, Robert RJ. Vitamin E. In Modern Nutrition
in Health and Disease, 8th ed. Lea & Febiger,
Phil.;1994:326-341
[2] Traber MG. Vitamin E. In Modern Nutrition in Health
and Disease, 9th ed. Williams & Wilkins, 1999:347-362
[3] An Overview of Vitamin E Efficacy. VERIS Research
Information Service, November 1998
[4] Burton GW, et al. Human plasma and tissue
alpha-tocopherol concentrations in response to
supplementation with deuterated natural and synthetic
vitamin E. Am J Clin Nutr, 199867(4):669-684
[5] Traber MG, Elsner A, Brigelius-Flohe R. Synthetic as
compared with natural vitamin E is preferentially
excreted as alpha-CEHC in human urine: studies using
deuterated alpha-tocopherol acetates. FEBS Letters,
1998;437:145-148
[6] ORAC Test by Brunswick Laboratories, Wareham (MA),
February 2006
[7] Sheldon SS, Rorvik D, ed. PDR for Nutritional
Supplements, 1 st ed. Medical Economics, Montvale (NJ),
2001
[8] Schlagheck TG, et al. Olestra"s effect on vitamins D
and E in humans can be offset by increasing dietary
levels of these vitamins. J Nutr,1997;127(8):1666S-1685S
[9] Avocados rise to the top. Nutr Week, 2001;31(24):7
[10] Rice bran, crude. USDA National Nutrient Database
for Standard Reference, Release 18, 2005
[11] Levander OA, Burk RF. Selenium. In Modern Nutrition
in Health and Disease, 8th ed. Lea & Febiger, Phil.,
1994:242-263
[12] El-Bayoumy K, Richie JP Jr, Boyiri T, Komninou D,
Prokopczyk B, Trushin N, Kleinman W, Cox J, Pittman B,
Colosimo S. Influence of Selenium-Enriched Yeast
Supplementation on Biomarkers of Oxidative Damage and
Hormone Status in Healthy Adult Males: A Clinical Pilot
Study. Cancer Epidemiol Biomarkers Prev.
2002;11:1459-1465
[13] Rottkamp CA, Nunomura A, Raina AK, et al. Oxidative
stress, antioxidants, and Alzheimer"s Disease. Alzheimer
Dis Assoc Disord, 2000;14(S1):S62-S66
[14] Ya-Jun, H, et al. The protective role of selenium
on the toxicity of cisplatin-contained chemotherapy
regimen in cancer patients. Bio Trace Element Res,
1997;56:331-341
[15] Clark LC, et al. Effects of selenium
supplementation for cancer prevention in patients with
carcinoma of the skin. JAMA, 1996; 276:1957-1963
[16] Williams D. Selenium: Better than a flu shot.
Alternatives for the Health Conscious Individual,
2002;9(18):142-143
[17] Budavari S, et al. The Merck Index, 12th ed. Merck
& Co., Whitehouse Station (NJ), 1996
[18] Rouhi AM. Escorting metal ions: protein chaperone
protects, guides, copper ions in transit. Chem Eng News,
1999;11:34-35
[19] Himelblau E, et al. Identification of a functional
homolog of the yeast copper homeostasis gene ATX1 from
Arabidopsis. Plant Physiol 1998;117(4):1227-1234
[20] Thomas JA. Oxidative stress, oxidant defense, and
dietary constituents. In Modern Nutrition in Health and
Disease, 8th ed. Lea & Febiger, Phil.;1994:501-512
[21] Null G. The Complete Encyclopedia of Natural
Healing. Kensington, NY, 1998
[22] Null G. The Clinician"s Handbook of Natural
Healing, Kensington, NY, 1998
[23] Thompson FE, et al. Sources of fiber and fat in the
diets of U.S. women ages 19 to 50: implications for
nutritional education and policy. Am J Pub Health 1992,
82(5):695-702
[24] Dietary fiber: importance of function as well as
amount. Lancet 1992, 340:1133-1134
[25] Jensen B. The Chemistry of Man. Bernard Jensen,
Escondido, 1983
[26] Nielsen FH. Ultratrace minerals. In Modern
Nutrition in Health and Disease, 9th ed. Williams and
Wilkins, Balt.;1999:283-303
Some of these studies (or citations) may not conform to
peer review standards (though most do). Therefore, the
results are not conclusive. Professionals can, and often
do, come to different conclusions when reviewing
scientific data.
None of these statements have been
reviewed by the FDA.
All products
distributed by Doctors" Research, Inc. are nutritional
and are not intended for the treatment or prevention of
any medical condition.
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